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    • ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform 

      Klec, Christiane; Knutsen, Erik; Schwarzenbacher, Daniela; Jonas, Katharina; Pasculli, Barbara; Heitzer, Ellen; Rinner, Beate; Krajina, Katarina; Prinz, Felix; Gottschalk, Benjamin; Ulz, Peter; Deutsch, Alexander; Prokesch, Andreas; Jahn, Stephan W.; Lellahi, Seyed Mohammad; Perander, Maria; Barbano, Raffaela; Graier, Wolfgang F.; Parrella, Paola; Calin, George Adrian; Pichler, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)
      The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role and molecular mode of action in breast carcinogenesis are completely unknown. Here, we identifed high ALYREF expression as a factor for poor survival in breast cancer patients. ALYREF signifcantly infuenced cellular growth, apoptosis and mitochondrial energy metabolism in ...